Fig. 1: Associations of each dimensional assessment in association with the four PRSs in multivariable analyses adjusted for age, se, bipolar disorder type, depressive symptoms and the six first components of the population’s genetic substructure. | Translational Psychiatry

Fig. 1: Associations of each dimensional assessment in association with the four PRSs in multivariable analyses adjusted for age, se, bipolar disorder type, depressive symptoms and the six first components of the population’s genetic substructure.

From: Polygenic risk scores for severe psychiatric disorders in bipolar disorders: associations with the clinical and dimensional expression, interactions with childhood maltreatment and mediation models

Fig. 1

Beta represent unstandardized coefficients obtained from the linear regressions of each dimension in association with the four PRS as dependent variables. adjusting for age, sex, BD type and MADRS score. All models were adjusted for the first six principal components of the population’s genetic substructure. For a question of clarity. unstandardized coefficients for age, sex, BD type, MADRS, and PCs are not displayed into the figures. Nominal p-values are indicated in brackets. A CTQ childhood trauma questionnaire (Log: log10 transformed), B WURS wender utah rating scale, C AIM affect intensity measure, D ALS affective lability scale, E BIS barrat impulsivity scale, F BDHIAtt buss durkee hostility inventory attitudinal component; G BDHIMot buss durkee hostility inventory motor component. PRS polygenic risk score, BD bipolar disorder, SZ schizophrenia, MDD major depressive disorder, ADHD attention deficit with hyperactivity disorder.

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