Table 1 Sample description (852 individuals with bipolar disorders).
Variables | N | % | Median | IQR | Missing |
|---|---|---|---|---|---|
Socio-demographic and clinical characteristics | |||||
Sex (females) | 538 | 63.1% | 0 | ||
Age at inclusion | 33 | 26–44 | 0 | ||
BD type 1 | 409 | 48.0% | 0 | ||
BD type 2 | 391 | 45.9% | |||
BD type NOS | 52 | 6.1% | |||
MADRS | 8 | 3–15 | 3 | ||
YMRS | 1 | 0–3 | 6 | ||
Age at BD onset | 21 | 17–26 | 37 | ||
Polarity at onset (depressive) | 592 | 71.8% | 27 | ||
Psychotic symptoms at onset | 128 | 15.5% | 27 | ||
Duration of illness | 11 | 5–18 | 38 | ||
Number of lifetime mood episodes | 6 | 3–10 | 34 | ||
Number of hospitalisations | 793 | 2 | 1–3 | 59 | |
Lifetime rapid cycling | 128 | 16.8% | 90 | ||
Lifetime suicidal attempt | 309 | 37.2% | 22 | ||
Comorbidities | |||||
Current smoker | 378 | 46.4% | 38 | ||
Lifetime alcohol use disorder | 201 | 26.6% | 97 | ||
Lifetime cannabis use disorder | 173 | 22.9% | 97 | ||
Lifetime anxiety disorders | 362 | 48.8% | 111 | ||
Medications at inclusion | |||||
Lithium | 277 | 39.9% | 158 | ||
Anticonvulsants | 358 | 51.5% | 157 | ||
Atypical antipsychotics | 286 | 43.0% | 187 | ||
Antidepressants | 236 | 35.5% | 187 | ||
Dimensionnal assessments | |||||
CTQ total score | 37 | 31–47 | 52 | ||
Childhood ADHD symptoms (WURS) | 29 | 17–46 | 61 | ||
Affect intensity measure (AIM) | 3.78 | 3.33–4.22 | 62 | ||
Affective lability scale (ALS) | 1.30 | 0.80–1.70 | 72 | ||
Barrat impulsivity scale (BIS) | 66 | 59–75 | 63 | ||
BDHI Attitudinal component | 8 | 4–11 | 90 | ||
BDHI Motor component | 20 | 15–27 | 96 | ||
Polygenic Risk Scores (PRS) | |||||
PRS-BD | 0.019 | −0.660–0.623 | 0 | ||
PRS-SZ | 0.013 | −0.693–0.715 | 0 | ||
PRS-MDD | 0.040 | −0.675–0.692 | 0 | ||
PRS-ADHD | 0.006 | −0.692–0.665 | 0 | ||
