Fig. 7: Model for Adgrl2 function in MECIII neurons. | Translational Psychiatry

Fig. 7: Model for Adgrl2 function in MECIII neurons.

From: Entorhinal cortex layer III Adgrl2 expression controls topographical circuit connectivity required for sequence learning

Fig. 7

(A) MECIII expressed Adgrl2 is organized in a topographical and layer specific fashion that overlaps with input specific axon targeting. Distal MEC inputs include projections from the ipsilateral/contralateral Proximal PrS that target MEC layer III, and contralateral distal MECIII projection neurons that target MEC layer I. (B) MEC circuitry impacts upon MECIII Adgrl2 deletion include targeting remodeling of select inputs arising from the ipsilateral proximal PrS and contralateral distal MECIII neurons.

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