Fig. 3: Glutamatergic TANsACC are significantly greater than that of GABAergic neurons in PTSD-like mice. | Translational Psychiatry

Fig. 3: Glutamatergic TANsACC are significantly greater than that of GABAergic neurons in PTSD-like mice.

From: Transcutaneous auricular vagus nerve stimulation alleviates anxiety-like behaviors in mice with post-traumatic stress disorder by regulating glutamatergic neurons in the anterior cingulate cortex

Fig. 3

(A) Schematic illustration of the Fos-TRAP strategy used to label TANsACC (Created with BioRender.com, 2025). (B) Statistical analysis shows that mCherry-­labeled neurons within the ACC co-localize with glutamate (Glu) and GABA antibodies, quantified as a percentage of the total DAPI-positive cell population [n = 8 mice per group. Mann-Whitney U test: Z = −3.3607, p = 0.0002]. (C) Representative images illustrating the infusion site within the ACC (left) and mCherry-­labeled neurons co-localizing with Glu (upper) or GABA (bottom) antibody (right). Scale bar, 250 μm (left) and 100 μm (right). Data represent the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.

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