Fig. 4: Manipulating SuM-DG circuit alters alertness and recognition in ADHD. | Translational Psychiatry

Fig. 4: Manipulating SuM-DG circuit alters alertness and recognition in ADHD.

From: Activation of the supramammillary-dentate gyrus circuit enhances alertness and cognitive function in a rat model of ADHD

Fig. 4

A Experimental timeline outlining the procedures for chemogenetic and optogenetic manipulations, including the schematic representation of viral vector delivery into the SuM. B Bar graph showing the percentage of time spent exploring a novel object in the NOR test under different experimental conditions. C Schematic of the experimental setup for visual looming stimulation, accompanied by a confocal microscopy image illustrating SuM illumination with blue light during optogenetic activation. D Bar graph comparing the average response times to 2# looming stimuli between control and ADHD rats under sham or optogenetic activation of SuM-DG circuit. E Line graph depicting the response times over five trials of looming stimulation of control or ADHD rats. F Bar graph showing the percentage of time spent exploring novel object in NOR test for control and ADHD rats.

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