Table 1 Characteristics of the studied WES samples in Yale-Penn cohort.

From: Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants

 

EUR (N = 2100)

AFR (N = 1790)

Age (mean ± SD)

37 ± 11

43 ± 9

Female (%)

755 (36.0)

635 (35.5)

Cases

1321

864

#Variants

 Singleton

374,384

319,831

 MAC ≥ 5

121,786

211,176

 MAF ≥ 0.01

57,336

103,067

 LoF

7921

7482

 Missense

259,413

272,956

 Synonymous

159,240

184,327

  1. Numbers of variants in different categories in each ancestry are listed.
  2. EUR European ancestry, AFR African ancestry, MAC minor allele count, MAF minor allele frequency, LoF loss-of-function.
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