Table 3 Top associated genes (p < 1 × 10−4) in the gene-based tests.
Gene | Category | MAF bin | Ancestry | P-value |
|---|---|---|---|---|
CHRND | synonymous | 0.01 | EUR + AFR | 4.39 × 10−6 |
SLC22A10 | synonymous | 0.001 | EUR | 1.55 × 10−5 |
TMCO3 | LoF+missense | 0.5 | EUR | 2.79 × 10−5 |
QPCTL | synonymous | 0.5 | EUR + AFR | 4.25 × 10−5 |
DHX58 | LoF+missense | 0.001 | AFR | 5.20 × 10−5 |
CHRND | synonymous | 0.01 | AFR | 5.99 × 10−5 |
FAM90A1 | LoF+missense+synoymous | 0.001 | EUR | 6.06 × 10−5 |
GLDN | LoF+missense+synoymous | 0.01 | AFR | 6.77 × 10−5 |
GLDN | LoF+missense+synoymous | 0.5 | AFR | 7.00 × 10−5 |
PLAT | LoF+missense | 0.5 | AFR | 7.00 × 10−5 |
COL3A1 | LoF+missense | 0.5 | EUR + AFR | 7.95 × 10−5 |
H1-4 | synonymous | 0.001 | AFR | 8.59 × 10−5 |
GPHB5 | LoF+missense | 0.5 | EUR + AFR | 9.50 × 10−5 |
