Fig. 4: Knockdown of Atg7 in Lateral Ventricle Can Also Alleviate Anxiety-like Behavior Caused by Foot shock Model. | Translational Psychiatry

Fig. 4: Knockdown of Atg7 in Lateral Ventricle Can Also Alleviate Anxiety-like Behavior Caused by Foot shock Model.

From: The downregulation of Autophagy in amygdala is sufficient to alleviate anxiety-like behaviors in Post-traumatic Stress Disorder model mice

Fig. 4

A Timeline and schematic of shCrl/shAtg7 stereotactic injection in foot shock model. B Behavioral paradigm of foot shock and fear memory extinction training. C Freezing time during extinction training (Two-way ANOVA, Sidak’s test). D Freezing time during recall and extinction section (Student’s, t-test). E Representative OFT trajectories. F OFT center time and total distance (One-way ANOVA, Tukey’s test). G Representative EPM trajectories. H EPM open arm entries and time (One-way ANOVA, Tukey’s test). Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. Group sizes: shCrl+NT (n = 6), shAtg7+NT (n = 6), shCrl+FS (n = 6), shAtg7+FS (n = 6). See also Fig. S2.

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