Fig. 6: Comprehensive characterization establishes TcMAC21 as a model to study cerebellar circuit changes in Trisomy 21. | Translational Psychiatry

Fig. 6: Comprehensive characterization establishes TcMAC21 as a model to study cerebellar circuit changes in Trisomy 21.

From: Altered motor coordination, vocal communication, and cerebellar circuit connectivity in mice carrying a near-complete human chromosome 21

Fig. 6

Summary schematic integrating key findings: Partial list of key observations in individuals with DS (left) and our parallel findings in the TcMAC21 model (right), suggesting that the TcMAC21 model provides insights into the cerebellar basis for motor deficits, extending beyond the traditional focus on cortical dysfunction.

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