Fig. 10: Wogonin attenuates renal autophagy disorder in type 1 diabetic mice. | Acta Pharmacologica Sinica

Fig. 10: Wogonin attenuates renal autophagy disorder in type 1 diabetic mice.

From: Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease

Fig. 10

a Immunohistochemistry analysis of p62 in human kidney tissues. Scale bar = 50 μm. Data represent the mean ± SEM for six humans. b Western blot analysis of Beclin-1, ATG7, p62, and LC3 in mice kidney tissues. c Representative transmission electron microscopy images of autophagosomes in mice kidney tissues, the arrows indicate autophagosomes. Scale bar = 500 nm. Data represent the mean ± SEM for 6–8 mice. ***P < 0.001 vs NC. #P < 0.05, ##P < 0.01, ###P < 0.001 vs STZ. NC normal control, Wog wogonin, STZ streptozotocin

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