Fig. 4: DHC downregulates inflammatory gene expression in BMDMs. | Acta Pharmacologica Sinica

Fig. 4: DHC downregulates inflammatory gene expression in BMDMs.

From: Antiatherosclerotic effect of dehydrocorydaline on ApoE−/− mice: inhibition of macrophage inflammation

Fig. 4

a The toxicity of DHC on BMDMs was determined by CCK-8 assays. b A volcano plot of the RNA-seq data showing comparisons of BMDMs treated with DMSO or 100 μM DHC for 24 h. n = 3. Red and green dots indicate significantly up- and downregulated genes, respectively (adjusted P < 0.01). c Top 20 KEGG pathways for the downregulated differentially expressed genes (DEGs). The circle size represents the gene number. The color gradient shows the adjusted P value. d Bar graph showing the FPKM values of genes related to the inflammatory response. The data are shown as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 vs. DMSO.

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