Fig. 5: DHC alleviates inflammation in BMDMs. | Acta Pharmacologica Sinica

Fig. 5: DHC alleviates inflammation in BMDMs.

From: Antiatherosclerotic effect of dehydrocorydaline on ApoE−/− mice: inhibition of macrophage inflammation

Fig. 5

a Relative mRNA levels of IL-1β and IL-18 in BMDMs treated with 100 μM DHC for 0, 6, and 12 h. n = 3–5. b Relative mRNA levels of IL-1β and IL-18 in BMDMs treated with 0, 50, and 100 μM DHC for 12 h. n = 3–5. c–d Immunoblots of CD80 and IL-18 in BMDMs treated with DMSO or DHC as indicated. n = 3–4. e Immunoblots showing CD80, iNOS, NLRP3, IL-1β, and IL-18 in BMDMs induced with 100 ng/mL LPS- and 20 ng/mL IFNγ (LPS/IFNγ) and treated with DMSO or DHC for 24 h. n = 3–4. The data are shown as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 vs. as indicated.

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