Fig. 3: MANF deficiency in macrophages aggravates DSS-induced mouse colitis. | Acta Pharmacologica Sinica

Fig. 3: MANF deficiency in macrophages aggravates DSS-induced mouse colitis.

From: MANF ameliorates DSS-induced mouse colitis via restricting Ly6ChiCX3CR1int macrophage transformation and suppressing CHOP-BATF2 signaling pathway

Fig. 3

a The time-dependent curves of body weight, diarrhea, and rectal bleeding. b Gross morphology of colons from WT and MKO mice. Colon length was measured on day 8. c Gross morphology of spleens from WT and MKO mice. Spleen weight was measured at day 8 and the ratio to body weight was calculated. d Representative H&E staining of colon sections and histology scores of WT and MKO mice. Bars: 100 μm. e Periodic acid–Schiff staining in colon sections of mice. Bars: 100 μm. f Survival percentage of WT and MKO mice. The mice were administered 4% DSS to induce acute colitis and the survival was monitored until day 13. All data are expressed as the mean ± SEM from 12 mice. *P < 0.05, **P < 0.01, ***P < 0.001, compared with WT.

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