Fig. 2: Effect of MPP+ and MPTP on the interaction of GHS-R1a and D2R in vitro and in vivo. | Acta Pharmacologica Sinica

Fig. 2: Effect of MPP+ and MPTP on the interaction of GHS-R1a and D2R in vitro and in vivo.

From: Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson’s disease mouse model through activating GHS-R1a/D2R heterodimers

Fig. 2

a The decrease of PC-12 cell density induced by MPP+ was observed by inverted fluorescence microscope; b The ultrastructure of PC-12 cells treated with MPP+ was observed by transmission electron microscope. Red arrows indicate mitochondria and blue arrows indicate the nuclear membrane; c Representative images of GHS-R1a/D2R PLA-positive dots in PC-12 cells of control and MPP+ group; d Analysis of GHS-R1a/D2R PLA-positive dots in the PC-12 cells treated with vehicle or 2 mM MPP+ for 24 h; e Representative images of GHS-R1a/D2R PLA-positive dots in WT mice and PD mice; f Analysis of GHS-R1a/D2R PLA-positive dots in the MPTP-treated PD mice. Data are depicted as bar graphs with as mean ± SEM. ***P < 0.001, n = 20.

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