Fig. 3: Effect of GHS-R1a/D2R heterodimers activation on cell viability. | Acta Pharmacologica Sinica

Fig. 3: Effect of GHS-R1a/D2R heterodimers activation on cell viability.

From: Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson’s disease mouse model through activating GHS-R1a/D2R heterodimers

Fig. 3

Effects of QNP (a) and MPP+ (b) on cell viability at indicated concentrations in PC-12 cells; c The efficiency of virus infection was detected by fluorescence microscope; d, e The protein and mRNA levels of GHS-R1a were decreased in shRNA-GHS-R1a-3 cells; f Pre-incubation with QNP (10 μM) antagonized MPP+ (2 mM)-induced reduction in cell viability in shRNA-NC group, as determined by CCK-8 assay. Data are depicted as bar graphs with mean ± SEM. *P < 0.05 vs. control, **P < 0.01 vs. control, ***P < 0.001 vs. control, *P < 0.05 vs. shRNA-NC, ***P < 0.001 vs. shRNA-NC, n = 12, 12, 3, 3, 12.

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