Fig. 2: Differential gene background would be the key determinant for the individualized response of AC cardiotoxicity. | Acta Pharmacologica Sinica

Fig. 2: Differential gene background would be the key determinant for the individualized response of AC cardiotoxicity.

From: HBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis

Fig. 2

a The LD50 of AC were measured in 8 progenitor mice of DO mice, either in female or in male mice, respectively (n = 10). b Survival ratio of 8 progenitor mice was measured (n = 10). c The behavior scores of progenitor mice were recorded within 0–360 min after exposed to AC at 0.405 mg/kg (1/3 of average LD50) (n = 4). d Representative images of progenitor mice after AC exposure. NOD/ShiLtJ mice suffered from vomiting, tachyarrhythmia, desudation, diarrhea, and convulsion, while in 129S1/SvImJ, no significant physical changes were observed. (**P < 0.01).

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