Fig. 2: CANA alleviates Su/Hx-induced mouse PH. | Acta Pharmacologica Sinica

Fig. 2: CANA alleviates Su/Hx-induced mouse PH.

From: Canagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation

Fig. 2

a Flowchart for Su/Hx-induced PH model establishment. b Quantitative analysis of the RVSP in Nx, Su/Hx and Su/Hx+CANA groups, (n = 6 mice per group). c Quantitative analysis of the mCAP in these groups (n = 6 mice per group). Quantitative analysis of RV/(S+LV) (d) and RV/WT (e) in these groups (n = 6 mice per group). Echocardiographic measurements illustrating PAT/PET (f), PAT (g), PAVTI (h) and RVFWT (i) in Nx, Su/Hx and Su/Hx+CANA groups (n = 6 mice per group). (j) Representative images of H&E staining, immunohistochemistry and Masson staining in Nx, Su/Hx and Su/Hx+CANA groups, Quantitative analysis of WA/TA (%) (k), WT/TT (%) (I), media thickness index (m), and the rate of fibrosis (n) of each group as shown in (j). n = 6 mice per group, four images per section. nsP > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Scale bars = 20 μm.

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