Fig. 7 | Acta Pharmacologica Sinica

Fig. 7

From: Canagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation

Fig. 7

CANA attenuates Su/Hx-induced PH partially by regulating PPARγ expression in vivo. a Flowchart for the rescue mouse PH model establishment. b Quantitative analysis of the RVSP in Nx, Su/Hx, Su/Hx + CANA, Su/Hx + CANA + GW9662, and Su/Hx + GW9662 groups. c Quantitative analysis of the mCAP in these groups (n = 6 mice per group). Quantitative analysis of RV/(S+LV) (d) and RV/BW (e) in these groups (n = 6 mice per group). f Representative images of H&E staining, immunohistochemistry and Masson staining in these five groups. Quantitative analysis of WA/TA(%) (g), WT/TT (%) (h), media thickness index (i), and the rate of fibrosis area (j) of each group as shown in (f). n = 6 mice per group, four images per section. nsP > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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