Fig. 8
CANA directly binds to PPARγ, inhibits PPARγ S225 phosphorylation. a SPR measurements of the CANA-PPARγ interaction. b Results of molecular docking simulations. c Upper panel: Representative chemiluminescence detection images detected PPARγ expression levels in mouse lung tissue of Nx, Hx, and Hx+CANA groups. Bottom panel: Quantitative analysis of PPARγ relative to β-ACTIN (n = 6 per group from six independent experiments). (d) Upper panel: Representative chemiluminescence detection images detected PPARγ expression levels in mouse lung tissue of Nx, Su/Hx and Su/Hx+CANA groups. Bottom panel: Quantitative analysis of PPARγ relative to β-ACTIN (n = 6 per group from six independent experiments). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
