Fig. 4: DHC inhibits PDGF-BB-induced VSMC proliferation and migration. | Acta Pharmacologica Sinica

Fig. 4: DHC inhibits PDGF-BB-induced VSMC proliferation and migration.

From: Dehydrocorydaline maintains the vascular smooth muscle cell contractile phenotype by upregulating Spta1

Fig. 4

a–c VSMCs were treated with 100 μM DHC and/or 20 ng/mL PDGF-BB for 36 h. The effects of PDGF-BB and DHC on VSMC proliferation were determined by cell counting a and a Cell Counting Kit-8 (CCK-8) assay (b), n = 3. c The effects of PDGF-BB and DHC on VSMC migration were examined using a wound healing assay (n = 3, scale = 150 μm). Data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001, analyzed using two-way ANOVA (a) and one-way ANOVA (b, c).

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