Fig. 1: Drug screening in zebrafish identifies gastrodin as a pro-myelinating agent. | Acta Pharmacologica Sinica

Fig. 1: Drug screening in zebrafish identifies gastrodin as a pro-myelinating agent.

From: Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling

Fig. 1

a Chemical structure of the TCM monomers (from ChemicalBook). b Schematic of drug screen pipeline. c Representative images depicting lateral view of the spinal cord in Tg(MBP:eGFP-CAAX) line at 5 dpf. Red box: location of zoomed-in example region (around 8–11 somites). d Mean fluorescence intensity of eGFP fluorescent intensity in the dorsal (above) and ventral (below) tracts of the spinal cord (n = 19–23 zebrafish). e Representative images depicting the dorsal tracts of the spinal cord in Tg(MBP:eGFP-CAAX) line at 5 dpf. Metformin serves as positive controls. f Mean fluorescence intensity of eGFP fluorescent intensity in the dorsal tracts of the spinal cord (n = 20 zebrafish). Data are represented as mean ± SEM, One-way ANOVA and Dunnett-t in d and f.

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