Fig. 5: O-GlcNAcylation controls the MM cell function via autophagy. | Acta Pharmacologica Sinica

Fig. 5: O-GlcNAcylation controls the MM cell function via autophagy.

From: Inhibition of CDC27 O-GlcNAcylation coordinates the antitumor efficacy in multiple myeloma through the autophagy-lysosome pathway

Fig. 5

Bar charts show the viability of MM.1S cells treated with 3-MA (1 mM) in the absence or presence of OSMI-1 a or gene knockdown with siOGT b. Representative images and bar charts show the flow cytometry analysis of the cell cycle in MM.1S cells treated with 3-MA in the absence or presence of OSMI-1 c or siOGT d. Representative images and bar charts show the flow cytometry analysis of cell apoptosis of MM.1S cells treated with 3-MA in the absence or presence of OSMI-1 e or siOGT f. The data were obtained from three independent experiments. The data are presented as the means ± SD. One-way ANOVA with Tukey’s multiple comparison test was used in a–f. ns not significant. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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