Fig. 6: Inhibition mTOR/NF-κB/IL-1β pathway confers to the antidepressant effects of COS. | Acta Pharmacologica Sinica

Fig. 6: Inhibition mTOR/NF-κB/IL-1β pathway confers to the antidepressant effects of COS.

From: Costunolide normalizes neuroinflammation and improves neurogenesis deficits in a mouse model of depression through inhibiting microglial Akt/mTOR/NF-κB pathway

Fig. 6

a The experimental timeline. b–e Behavioral tests showed that MHY1485 (10 μM, 1 μL per side) reversed the antidepressant effects produced by COS (20 mg/kg, i.p.) in CRS-exposed mice, including decreased sucrose preference in SPT (b), increased immobile time in TST (c) and FST (d), and decreased grooming time in ST (e) (n = 7 mice per group). f The experimental timeline. g-j Behavioral test showed that IL-1β (5 μg/kg, 1 μL per side) abolished antidepressant effects induced by COS in CRS-exposed mice, including decreased sucrose preference in SPT (g), increased immobile time in TST (h) and FST (i), and decreased grooming time in ST (j) (n = 7 mice per group). Data are presented as mean ± SEM, *P < 0.05, ***P < 0.001 by two-way ANOVA (b–e, g–j) followed by Sidak’s post hoc test.

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