Fig. 2: Overexpression of circSARS-CV2-Ns enhances platelet adhesiveness onto HCMECs. | Acta Pharmacologica Sinica

Fig. 2: Overexpression of circSARS-CV2-Ns enhances platelet adhesiveness onto HCMECs.

From: CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-κB/ROS signaling

Fig. 2

a Detection of SARS-CV2-Ns overexpression in HCMECs by RT-qPCR assay. b Identification of the junction site sequence of adenovirus-mediated expression of circSARS-CV2-N654, -N804, and -N1368 by Sanger DNA sequencing assay. c Overexpression of circSARS-CV2-N654, -N804, -N1368 promoted platelet adhesiveness onto HCMECs (1-way ANOVA, n = 3 per group). d MRNA expression of inflammatory-related genes in HCMECs by RT-qPCR assay (1-way ANOVA, n = 3 per group). *P < 0.05; **P < 0.01; ***P < 0.001.

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