Fig. 3: HuR knockdown shows anti-MM effects in vivo.
From: Targeting the HuR/E2F7 axis synergizes with bortezomib against multiple myeloma
a NCI-H929 and OPM2 cells transfected with lentiviruses (shNC, shHuR#1 or shHuR#2) were inoculated subcutaneously into NOG mice to construct xenograft mouse models. These subcutaneous tumors were dissected from each group of mice and photographed at the end of the experiment (n = 5). b Subcutaneous tumors from the above groups of mice were measured, weighed, and compared. c Subcutaneous tumors from three groups of mice, shNC, shHuR#1, and shHuR#2, were embedded in paraffin and stained with hematoxylin and eosin (HE), Ki67, and cleaved caspase 3 antibody (scale 100 μm). The data are shown as the means ± SD and were analyzed by one-way ANOVA. ***P < 0.001, ****P < 0.0001.
