Fig. 7: Diagram of the regulatory effect of circDhx32 on cardiac I/R injury. | Acta Pharmacologica Sinica

Fig. 7: Diagram of the regulatory effect of circDhx32 on cardiac I/R injury.

From: Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia-reperfusion injury via binding to FOXO1 competed with AdipoR1

Fig. 7

YTHDF2 and YTHDC1 recognize fewer m6A modification sites on circDhx32 caused by ALKBH5 and increase its stability and nuclear retention in cardiac I/R model mice. Nuclear circDhx32 binds to FOXO1 and then competitively relieves its ability to activate AdipoR1, ultimately inhibiting the expression of AdipoR1 and thereby exacerbating the inflammatory response in cardiac I/R model mice by regulating the AMPK/NF-κB signaling pathway.

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