Table 2 Relevant upstream transcription regulators at 200, 500, and 1000 μM of ASA treatments.

From: Gene expression profiling on effect of aspirin on osteogenic differentiation of periodontal ligament stem cells

Canonical pathway

200 μM

500 μM

1000 μM

TREM1 signaling

−2.0

−2.1213

−2.1106

Role of pattern recognition receptors in recognition of bacteria and viruses

N/A

−2.3333

−3.5000

Growth hormone signaling

N/A

−2.2361

−2.6458

Production of nitric oxide and reactive oxygen species in macrophages

N/A

−2.7136

−2.13200

Interferon signaling

N/A

−2.000

−2.44949

NF-κB signaling

N/A

−2.333333

−2.0000

Renin-angiotensin signaling

N/A

−1.6667

−2.3238

Colorectal cancer metastasis signaling

N/A

−1.9415

−2.0412

Activation of IRF by cytosolic pattern recognition receptors

N/A

−1.6330

−2.12132

Thrombopoietin signaling

N/A

−1.6330

−2.1213

CDK5 signaling

0.0

−2.000

−1.73205

Acute myeloid leukemia signaling

N/A

−2.1213

−1.5076

Protein kinase A signaling

N/A

−1.14708

−2.3591

Agrin interactions at neuromuscular junction

0.0

2.23607

1.1339

EIF2 signaling

0.0

N/A

−2.8402

Role of IL-17F in allergic inflammatory airway diseases

N/A

N/A

−2.2361

Inhibition of angiogenesis by TSP1

N/A

N/A

2.23607

Role of RIG1-like receptors in antiviral innate immunity

0.0

N/A

−2.2360

Regulation of cellular mechanics by calpain protease

0.0

N/A

2.0000

  1. Most activated or inhibited upstream transcription regulators as estimated by the z-score for each comparison from Ingenuity Pathway Analysis.
  2. N/A not available.