Table 1 List of inclusion and exclusion criteria.

18 to 60 years old, in good general health

Having a medical condition that requires premedication prior to dental visits/procedures

No known history of allergy to personal care/consumer products

Having history of allergy to common toothpaste ingredients

A minimum of 20 natural uncrowned teeth (excluding third molars)

Not enough teeth to secure the intra-oral appliance

No active unrestored cavities

Wearing orthodontic appliances

A normal salivary flow rate (stimulated and unstimulated flow of ≥ 0.7 mL/min and ≥ 0.2 mL/min, respectively)

Having an impaired salivary function or Using drugs that can affect salivary flow

Willing to give written informed consent

Having diseases of the soft or hard oral tissues

Willing to be available throughout entire study

Using antibiotics one month prior to or during this study,

Be willing to wear intra-oral appliance 24 h per day

Participating in another clinical study one week prior to the start of the washout period or during this study period

Willing to use only assigned products for oral hygiene throughout the duration of the study

Using tobacco products

Having an advanced periodontal disease

Having a compromised immune system (HIV, AIDS, immuno-suppressive drug therapy).