Table 4 Summary of Primary outcome measures
Outcome measure | Day | Guida et al. [43] | Liu et al. [44] | Chen and colleagues | |
|---|---|---|---|---|---|
Wang et al. [25] | Cao et al. [1] | ||||
Cell proliferation (Absorbance value) | 3 | Not assessed | cp-Ti: 0.97 ± 0.04 TNT: 0.96 ± 0.04 (p>0.05) | cp-Ti: 1.37 ± 0.1 TNT: 1.44 ± 0.13 No significant difference: p value not reported | cp-Ti: 0.28 ± 0.02 TNT: 0.29 ± 0.01 No significant difference: p value not reported |
7 | cp-Ti: Median: 0.12 LQ: 0.106 UQ: 0.135 Min: 0.08 Max: 0.1 TNT Median: 0.43 LQ: 0.36 UQ: 0.45 Min: 0.34 Max: 0.57 (p<0.001) | cp-Ti:1.27 ± 0.02 TNT: 1.26 ± 0.02 No significant difference: p value not reported | cp-Ti: 2.11 ± 0.02 TNT: 2.37 ± 0.03 (p<0.001) | cp-Ti: 0.37 ± 0.03 TNT: 0.44 ± 0.04 (p<0.05) | |
14 | Not assessed | cp-Ti:1.41 ± 0.01 TNT: 1.48 ± 0.01 (p<0.05) | Not assessed | Not assessed | |
FN protein expression (Concentration value) | 6 | Not assessed | Not assessed | Not assessed | cp-Ti: 189 ± 3 ng/ml TNT: 239 ± 7 ng/ml (p<0.05) |
7 | Not assessed | Not assessed | cp-Ti: 293.59 ± 9.85 ng/ml TNT: 329.06 ± 7.88 ng/ml (p<0.01) | Not assessed | |
COL-1 protein expression (Concentration value) | 6 | Not assessed | Not assessed | Not assessed | cp-Ti: 252 ± 12 ng/ml TNT: 278 ± 4 ng/ml (p<0.05) |
7 | cp-Ti: Median: 17.25 ng/ml/cell LQ: 14.49 ng/ml/cell UQ: 17.67 ng/ml/cell Min: 13.71 ng/ml/cell Max: 18.59 ng/ml/cell TNT: Median 21.92 ng/ml/cell LQ: 21.06 ng/ml/cell UQ: 22.66 ng/ml/cell Min: 20.44 ng/ml/cell Max: 23.62 ng/ml/cell (p<0.001) | cp-Ti: 4.73 ± 0.03 U/ml TNT: 6.2 ± 0.1 U/ml (p<0.05) | cp-Ti: 299.99 ± 29.27 ng/ml TNT: 302.43 ± 21.96 ng/ml No significant difference: p value not reported Not assessed | Not assessed | |
14 | Not assessed | cp-Ti 5.97 ± 0.07 U/ml TNT 5.59 ± 0.14 U/ml (P<0.05). | Not assessed | ||
