Fig. 2 | Blood Cancer Journal

Fig. 2

From: CALR mutational status identifies different disease subtypes of essential thrombocythemia showing distinct expression profiles

Fig. 2

IPA canonical pathways and upstream regulator analysis of DEG in CALR-mutated vs. JAK2V617F-positive ET. a, b IPA canonical pathways more represented in the list of DEG a mTOR signaling; b MAPK/PI3K signaling. The networks also show the predicted mRNA–miRNA interactions identified by IPA’s miRNA Target Filter. Green and red colors indicate genes/miRNA down- and upregulated, respectively, in the pairwise comparison CALR-mutated vs. JAK2V617F-positive ET c IPA upstream regulator analysis indicated the inhibition of MYC activity predicted by the decreased expression of its targets. Green colors indicate genes downregulated in the pairwise comparison CALR-mutated vs. JAK2V617F-positive ET. The blue lines display the inhibitory effect of proteins, which was confirmed by IPA Knowledge database. The gray lines indicate that the protein interactions lacked literature support to predict the activation effect. Solid lines: direct interactions; dashed lines: indirect interactions; d The histogram shows the differential expression of genes involved in cell cycle regulation and DNA replication between CALR-mutated vs. JAK2V617F-positive samples. The green block indicates a decreased expression, while the red block indicates an increased expression in the pairwise comparison CALR-mutated vs. JAK2V617F-positive ET

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