Fig. 3 | Blood Cancer Journal

Fig. 3

From: CALR mutational status identifies different disease subtypes of essential thrombocythemia showing distinct expression profiles

Fig. 3

DNA repair pathways in CALR-mutated vs. JAK2V617F-positive ET. a, b IPA canonical pathways highly represented in the list of DEG a BRCA1 in the DNA damage response; b ATM signaling. The networks also show the predicted mRNA–miRNA interactions identified by IPA’s miRNA Target Filter. Green and red colors indicate genes/miRNA down- and upregulated, respectively, in the pairwise comparison CALR-mutated vs. JAK2V617F-positive ET. c The histogram shows the differential expression between CALR-mutated vs. JAK2V617F-positive samples of genes involved in DNA repair. The green block indicates a decreased expression, while the red block indicates an increased expression in the pairwise comparison CALR-mutated vs. JAK2V617F-positive ET

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