Fig. 4 | Blood Cancer Journal

Fig. 4

From: CALR mutational status identifies different disease subtypes of essential thrombocythemia showing distinct expression profiles

Fig. 4

Deregulated expression of CSNK1A1 , chromatin remodeling, cohesin complex, and splicing factors in CALR-mutated ET. a Box plot shows the decreased expression level of CSNK1A1 in CALR-mutated ET. The lower part of the panel shows the overexpression of two miRNAs targeting CSNK1A1. Green and red colors indicate genes/miRNA down- and upregulated, respectively, in the pairwise comparison CALR-mutated vs. JAK2V617F-positive ET. b–d The histograms show the differential expression between CALR-mutated vs. JAK2V617F-positive samples of genes involved in b chromatin remodeling c cohesin complex d splicing factors. The green block indicates a decreased expression in the pairwise comparison CALR-mutated vs. JAK2V617F-positive ET

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