Table 1 Mutation frequencies of 25 myeloid genes

From: Incorporation of mutations in five genes in the revised International Prognostic Scoring System can improve risk stratification in the patients with myelodysplastic syndrome

Variables

No. examined

Mutated no.

Percentage (%)

RAS signaling pathway

426

37

8.7

 NRAS

426

19

4.5

 KRAS

426

6

1.4

 CBL

426

13

3.1

Receptors/kinases

426

9

2.1

 FLT3/ITD

426

5

1.2

 JAK2

426

4

0.9

Transcription

426

61

14.3

 RUNX1

426

52

12.2

 GATA2

426

11

2.6

DNA methylation

426

104

24.4

 IDH1

426

4

0.9

 IDH2

426

18

4.2

 DNMT3A

426

42

9.9

 TET2

426

59

13.8

Chromatin modification

426

103

24.2

 ASXL1

426

96

22.5

 EZH2

426

27

6.3

 MLL/PTD

426

5

1.2

RNA splicing

426

166

39

 U2AF1

426

31

7.3

 SRSF2

426

58

13.6

 SF3B1

426

47

11.0

 ZRSR2

426

41

9.6

Cohesin

426

31

7.3

 RAD21

426

0

0

 STAG1

426

2

0.5

 STAG2

426

27

6.3

 SMC1A

426

2

0.5

 SMC3

426

0

0

Others

426

55

12.9

 SETBP1

426

14

3.3

 TP53

426

41

9.6

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