Fig. 2: Risk stratification of smoldering multiple myeloma in a subset of patients with FISH testing and advanced imaging available at diagnosis.
From: Risk stratification of smoldering multiple myeloma incorporating revised IMWG diagnostic criteria
a Kaplan–Meier failure curves showing time to progression (TTP) in patients with none (low risk), one (intermediate risk), and two or more (high risk) of bone marrow-plasma cell percentage (BMPC%) > 20%, free light chain ratio (FLCr) > 20, and high-risk cytogenetics [del17p, t(4;14) or hyperdiploidy]. The estimated median TTP in the three groups were not reached (95% CI, 33.3 months–NR), 63.0 months (95% CI, 29.8–NR), and 14.5 months (95% CI, 10.7–25.4), respectively (p < 0.0001). b Kaplan–Meier failure curves for patients stratified according to the conventional Mayo Clinic model by presence of one (low risk), two (intermediate risk), and three (high risk) of monoclonal protein ≥ 3 g/dL, BMPC% ≥ 10%, and FLCr ≥ 8 at diagnosis. The estimated median TTP in the three groups were NR (95% CI, 29.8 months–NR), 35.1 months (95% CI, 13.4–47.0), and 18.9 months (95% CI, 5.8–NR), respectively (p = 0.043)
