Fig. 5: The cardiac glycosides strophanthidin, digoxin and ouabain are cytotoxic against primitive AML cells.
From: Leukemic stem cell signatures identify novel therapeutics targeting acute myeloid leukemia
a Colony formation of AML 8227 treated with 30 nM of strophanthidin for 4 days. Data are representative of two independent experiments performed in quadruplicate and represents mean ± s.d. b Viability of additional primary AML treated with strophanthidin, digoxin and ouabain at indicated concentrations for 4 days. Data represent mean ± s.d; experiment performed in triplicate. c Viability of CD34+ cord blood cells and CD34+ 8227 cells treated with strophanthidin, digoxin and ouabain at indicated concentrations for 4 days. Data are representative of at least two independent experiments performed in triplicate and represent the mean ± s.d. ***p ≤ 0.001
