Table 1 Drugs confirmed to be effective against AML 8227

From: Leukemic stem cell signatures identify novel therapeutics targeting acute myeloid leukemia

Compound name

Screen category

Class

Approved (e.g. FDA)

Rule of 5

Astemizole

1

Anti-histamine

Yesa

No

Terfenadine

1

Anti-histamine

Yesa

No

Simvastatin

2

Lipid-lowering

Yes

Yes

Sulconazole

2

Anti-infective

Yes

Yes

Budesonide

2

Corticosteroid

Yes

Yes

Halcinonide

2

Corticosteroid

Yes

Yes

Mometasone

2

Corticosteroid

Yes

Yes

Menadione

2

Vitamin

Yesb

Yes

Ebselen

2

Other

No

Yes

H-7

2

Other

No

Not available

Proadifen

2

Other

No

Yes

Digoxin

2

Cardio-vascular

Yes

Yes

Strophanthidin

2

Cardio-vascular

No

Yes

Ouabain

2

Cardio-vascular

No

Yes

  1. aWithdrawn from the market
  2. bDiscontinued from the market