Table 4 GAs and pathways associated with response and/or survival

From: Integrated DNA/RNA targeted genomic profiling of diffuse large B-cell lymphoma using a clinical assay

Gene

N

HR PFS (95% CI)

p value

BH p

HR OS (95% CI)

p value

BH p

CDKN2A

25

1.4 (0.6, 3.0)

0.391

0.687

1.7 (0.6, 4.4)

0.314

0.847

KMT2D

25

1.8 (0.9, 3.8)

0.103

0.428

1.2 (0.4, 3.3)

0.754

0.896

BCL2

21

1.9 (0.9, 4.0)

0.114

0.428

0.9 (0.3, 3.1)

0.853

0.896

B2M

20

1.4 (0.6, 3.1)

0.483

0.725

2.9 (1.1, 7.6)

0.027

0.204

BCL6

19

0.4 (0.1, 1.4)

0.161

0.482

0.9 (0.3, 3.1)

0.866

0.896

TP53

19

4.5 (2.1, 9.5)

<0.0001

0.001

5.8 (2.1, 16.0)

0.001

0.011

CREBBP

18

1.5 (0.7, 3.5)

0.319

0.687

1.9 (0.7, 5.4)

0.225

0.844

MYD88

18

1.4 (0.6, 3.3)

0.408

0.687

0.6 (0.1, 2.7)

0.534

0.847

CDKN2B

15

2.2 (0.9, 5.0)

0.076

0.428

2.5 (0.9, 7.1)

0.079

0.395

TNFAIP3

15

0.7 (0.2, 2.3)

0.569

0.764

1.4 (0.4, 5.0)

0.564

0.847

EZH2

14

0.7 (0.2, 2.4)

0.611

0.764

0.4 (0.1, 3.2)

0.411

0.847

REL

12

0.5 (0.1, 2.3)

0.412

0.687

0.9 (0.2, 3.9)

0.896

0.896

PIM1

11

0.9 (0.3, 2.8)

0.800

0.858

0.4 (0.0, 2.9)

0.348

0.847

TNFRSF14

11

1.0 (0.3, 3.4)

0.972

0.972

0.6 (0.1, 4.2)

0.565

0.847

Pathway

Ā Ā Ā Ā Ā Ā Ā 

ā€ƒTranslation

10

2.3 (0.9, 6.0)

0.091

0.453

4.9 (1.7, 13.8)

0.003

0.039

ā€ƒTumor suppressor/p53

56

3.2 (1.5, 7.0)

0.003

0.052

4.3 (1.4, 13.2)

0.011

0.081

ā€ƒImmune evasion

31

1.1 (0.5, 2.3)

0.886

0.961

2.2 (0.9, 5.6)

0.095

0.473

ā€ƒEpigenetic histone all

49

1.9 (0.9, 3.8)

0.083

0.453

1.9 (0.7, 4.9)

0.184

0.689

  1. Differing values with unadjusted p < 0.05 depicted in bold
  2. BH FDR-adjusted p value (Benjaminiāˆ’Hochberg), R/R relapsed refractory, SNV short nucleotide variant, tFL transformed follicular lymphoma