Table 4 GAs and pathways associated with response and/or survival
Gene | N | HR PFS (95% CI) | p value | BH p | HR OS (95% CI) | p value | BH p |
|---|---|---|---|---|---|---|---|
CDKN2A | 25 | 1.4 (0.6, 3.0) | 0.391 | 0.687 | 1.7 (0.6, 4.4) | 0.314 | 0.847 |
KMT2D | 25 | 1.8 (0.9, 3.8) | 0.103 | 0.428 | 1.2 (0.4, 3.3) | 0.754 | 0.896 |
BCL2 | 21 | 1.9 (0.9, 4.0) | 0.114 | 0.428 | 0.9 (0.3, 3.1) | 0.853 | 0.896 |
B2M | 20 | 1.4 (0.6, 3.1) | 0.483 | 0.725 | 2.9 (1.1, 7.6) | 0.027 | 0.204 |
BCL6 | 19 | 0.4 (0.1, 1.4) | 0.161 | 0.482 | 0.9 (0.3, 3.1) | 0.866 | 0.896 |
TP53 | 19 | 4.5 (2.1, 9.5) | <0.0001 | 0.001 | 5.8 (2.1, 16.0) | 0.001 | 0.011 |
CREBBP | 18 | 1.5 (0.7, 3.5) | 0.319 | 0.687 | 1.9 (0.7, 5.4) | 0.225 | 0.844 |
MYD88 | 18 | 1.4 (0.6, 3.3) | 0.408 | 0.687 | 0.6 (0.1, 2.7) | 0.534 | 0.847 |
CDKN2B | 15 | 2.2 (0.9, 5.0) | 0.076 | 0.428 | 2.5 (0.9, 7.1) | 0.079 | 0.395 |
TNFAIP3 | 15 | 0.7 (0.2, 2.3) | 0.569 | 0.764 | 1.4 (0.4, 5.0) | 0.564 | 0.847 |
EZH2 | 14 | 0.7 (0.2, 2.4) | 0.611 | 0.764 | 0.4 (0.1, 3.2) | 0.411 | 0.847 |
REL | 12 | 0.5 (0.1, 2.3) | 0.412 | 0.687 | 0.9 (0.2, 3.9) | 0.896 | 0.896 |
PIM1 | 11 | 0.9 (0.3, 2.8) | 0.800 | 0.858 | 0.4 (0.0, 2.9) | 0.348 | 0.847 |
TNFRSF14 | 11 | 1.0 (0.3, 3.4) | 0.972 | 0.972 | 0.6 (0.1, 4.2) | 0.565 | 0.847 |
Pathway | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āTranslation | 10 | 2.3 (0.9, 6.0) | 0.091 | 0.453 | 4.9 (1.7, 13.8) | 0.003 | 0.039 |
āTumor suppressor/p53 | 56 | 3.2 (1.5, 7.0) | 0.003 | 0.052 | 4.3 (1.4, 13.2) | 0.011 | 0.081 |
āImmune evasion | 31 | 1.1 (0.5, 2.3) | 0.886 | 0.961 | 2.2 (0.9, 5.6) | 0.095 | 0.473 |
āEpigenetic histone all | 49 | 1.9 (0.9, 3.8) | 0.083 | 0.453 | 1.9 (0.7, 4.9) | 0.184 | 0.689 |