Table 1 Patient characteristics and VTE risk

From: Risk factors for venous thromboembolism in patients with lymphoma requiring hospitalization

 

All VTE

Symptomatic VTE

Parameter

Number of patients

Univariate analysis

Multivariate analysis

Univariate Analysis

Multivariate Analysis

OR

95% CI

P value

OR

95% CI

P value

OR

95% CI

P value

OR

95% CI

P value

Age > 60 years (n = 857)

384 (44.8%)

1.61

1.05–2.49

0.03

1.12

0.70–1.90

0.7

1.71

0.99–2.95

0.06

   

Male gender (n = 857)

431 (50.3%)

1.05

0.69–1.61

0.8

   

1.19

0.70–2.04

0.5

   

Aggressive histologya (n = 857)

585 (68.3%)

2.17

1.23–3.72

0.007

0.74

0.53–1.03

0.08

2.61

1.26–5.40

0.01

1.10

0.47–2.60

0.8

PCNSL (n = 857)

33 (3.9%)

3.22

1.45–7.15

0.004

3.70

1.41–9.69

0.008

 

5.06

2.17–11.2

 < 0.001

6.32

2.21–18.2

Stage, III–IV (n = 849)

537 (63.2%)

1.34

0.84–2.13

0.2

   

0.89

0.51–1.55

0.7

   

Bulk > 10 cm (n = 849)

208 (24.5%)

2.67

1.71–4.15

0.001

3.23

1.85–5.63

0.0001

2.04

1.17–3.58

0.01

2.84

1.42–5.72

0.003

ECOG ≥ 2 (n = 849)

270 (31.8 %)

3.28

2.10–5.10

0.001

1.80

1.03–3.13

0.04

4.26

2.39–7.60

 < 0.001

2.56

1.28–5.11

0.008

WBC > 11 × 109/l (n = 831)

179 (21.5%)

1.31

0.80–2.15

0.3

   

1.70

0.93–3.08

0.08

   

Plt > 350 × 109/l (n = 832)

233 (28%)

0.83

0.50–1.36

0.5

   

0.48

0.23–1.0

0.05

   

Hb < 10 g/dl (n = 839)

147 (17.5%)

1.06

0.61–1.85

0.8

   

1.34

0.70–2.61

0.4

   

Albumin < 4 g/dl (n = 736)

417 (56.7%)

2.5

1.45–4.30

0.001

1.74

0.95–3.19

0.07

2.27

1.16–4.46

0.02

1.31

0.62–2.79

0.4

LDH elevated > UNV (n = 835)

314 (37.6%)

2.30

1.49–3.58

0.001

1.07

0.62–1.86

0.8

2.03

1.42–3.51

0.01

1.34

0.66–2.71

0.5

  1. P values < 0.05 are shown in bold
  2. Multivariate logistic regression analysis included 717 patients
  3. OR odds ratio, PCNSL primary central nervous system lymphoma, WBC white blood cell count, Plt platelet count, Hb hemoglobin, UNV upper normal value
  4. aAggressive histology includes diffuse large B cell lymphoma, mantle cell lymphoma and peripheral T-cell lymphoma; follicular lymphoma and Hodgkin lymphoma were considered non-aggressive histology
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