Table 3 Treatment administration
All patients | Phase 2 dose | |
|---|---|---|
(N = 48) | (N = 45) | |
Ixazomib | ||
Number of cycles | 620 | 561 |
Median dose (mg, Range) | 12 (3–120) | 12 (3–120) |
Number of patients with dose reductions | 6 (13%) | 6 (13%) |
Total number of dose reductions | 8 | 8 |
Cyclophosphamide | ||
Number of cycles | 382 | 357 |
Median dose (mg, Range) | 2800 (0–5000) | 3000 (0–5000) |
Number of patients with dose reductions | 16 (33%) | 16 (36%) |
Total number of dose reductions | 24 | 24 |
Dexamethasone | ||
Number of cycles | 386 | 361 |
Median dose (mg, range) | 160 (0–160) | 160 (0–160) |
Number of patients with dose reductions | 20 (42%) | 18 (40%) |
Total number of dose reductions | 29 | 26 |
Treatment delays | ||
Number of patients | 14 (25%) | 12 (27%) |
Total number of delays | 19 | 15 |
