Fig. 4: Tumoral heterogeneity.

a Metabolic tumor volume according to the coefficient of heterogeneity (H = (Number of mutations in tumor DNA−Number of mutations in cfDNA)/Number of mutations in tumor DNA). The red dots represent the patients with more mutations detected in the cfDNA than in the tumoral DNA (H < 0). b Boxplot representation of the MTV values according to the presence (red dots, H < 0) or absence (blue dots, H ≥ 0) of supplementary mutations in the cfDNA. c 3D view of PET scan images for the four patients presenting supplementary mutations in the cfDNA, with MTV in orange boxes and TLG in green boxes