Fig. 2: Targeted inhibition of JAK2V617F progenitors in vitro and in vivo
From: Ropeginterferon alpha-2b targets JAK2V617F-positive polycythemia vera cells in vitro and in vivo
A Clonogenic assays on primary peripheral blood mononuclear cells from 4 PV patients. Median percentages and standard deviations of residual erythroid colonies in treated conditions compared to untreated are presented. B and C JAK2V617F allele burden evolution in patients included in the PROUD-PV trial in France. B median of the %JAK2V617F in HU (N = 5) or Ropeg (N = 3) treatment arms. C Comparison of the % reduction of JAK2V617F allele burden in patients after 1 year of treatment in each arm. Median and standard deviations in both groups of treatment are represented. (*p < 0.02; unpaired t-test). D and E Clonogenic assays performed on bone marrow samples from patients included in the PROUD-PV trial in France. Percentages of JAK2V617F positive erythroid colonies before and after 1 year of treatment in patients treated with Ropeg or HU. UPN of each individual patient is given
