Table 1 Most accurate cutoff to discriminate between MM and MGUS cases based on the absolute number of PB circulating tumor PC

From: Next generation flow for minimally-invasive blood characterization of MGUS and multiple myeloma at diagnosis based on circulating tumor plasma cells (CTPC)

Variable

No. of CTPC/μL of PB

Cutoff value

0.058 CTPC/μL

Sensitivity

80%

Specificity

80%

AUC

88%

Positive predictive value (%)

65%

Negative predictive value (%)

90%

No. of MGUS cases below cutoff/total (%)

120/150 (80%)**

No. of MM cases above cutoff/total (%)

55/68 (81%)

False-positive cases (%)

30/150 (20%)

False-negative cases (%)

13/68 (19%)

  1. PB peripheral blood, PC plasma cell, CTPC circulating tumor PC, MGUS monoclonal gammopathy of undetermined significance, MM symptomatic multiple myeloma, AUC area under the curve, No. number.
  2. *p <0.0001. **6/30 (20%) MGUS cases above the cutoff have progressed to MM after a median follow-up of 17 months
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