Table 2 Logistic regression, 10-year survival vs. 2-year death

From: Clinical predictors of long-term survival in newly diagnosed transplant eligible multiple myeloma — an IMWG Research Project

 

Factors differentiating 10-year survival vs. 2-year death

Variable

N

Survival less than 2 years

Survival more than 10 years

OR (95% CI)

P-value

Univariate

Age at registration > = 65 yr

2374

163/214 (76%)

1271/2160 (59%)

2.24 (1.61, 3.10)

 < 0.001

IgA

1878

306/463 (66%)

785/1415 (55%)

1.56 (1.26, 1.95)

 < 0.001

IgG

1878

580/1080 (54%)

511/798 (64%)

0.65 (0.54, 0.79)

 < 0.001

Female

1918

493/827 (60%)

685/1091 (63%)

0.87 (0.73, 1.05)

0.157

Albumin < 3.5 g/dL

2206

559/808 (69%)

737/1398 (53%)

2.01 (1.68, 2.42)

 < 0.001

B2M > = 3.5 mg/L

2208

833/1123 (74%)

488/1085 (45%)

3.51 (2.94, 4.20)

 < 0.001

B2M > 5.5 mg/L

2208

501/630 (80%)

820/1578 (52%)

3.59 (2.89, 4.46)

 < 0.001

Creatinine > = 2 mg/dL

2320

353/430 (82%)

1042/1890 (55%)

3.73 (2.87, 4.85)

 < 0.001

HGB < 10 g/dL

2313

678/908 (75%)

699/1405 (50%)

2.98 (2.48, 3.57)

 < 0.001

LDH > Upper Limit Normal

935

196/260 (75%)

354/675 (52%)

2.78 (2.02, 3.82)

 < 0.001

Platelet Count < 150 × 10^9/L

2241

364/443 (82%)

969/1798 (54%)

3.94 (3.04, 5.11)

 < 0.001

Any clonal abnormality by cytogenetics

507

92/145 (63%)

127/362 (35%)

3.21 (2.15, 4.80)

 < 0.001

BMPC > = 30%

1933

800/1226 (65%)

317/707 (45%)

2.31 (1.91, 2.79)

 < 0.001

ISS Stage 1

2070

296/761 (39%)

910/1309 (70%)

0.28 (0.23, 0.34)

 < 0.001

ISS Stage 2

2105

477/756 (63%)

759/1349 (56%)

1.33 (1.11, 1.60)

0.002

ISS Stage 3

2208

501/630 (80%)

820/1578 (52%)

3.59 (2.89, 4.46)

 < 0.001

Multivariate (stratified by country)

Age at registration > = 65 yr

1230

98/144 (68%)

525/1086 (48%)

1.87 (1.26, 2.79)

0.002

IgA

1230

180/298 (60%)

443/932 (48%)

1.53 (1.15, 2.04)

0.004

Albumin < 3.5 g/dL

1230

294/474 (62%)

329/756 (44%)

1.36 (1.04, 1.78)

0.023

B2M > = 3.5 mg/L

1230

376/569 (66%)

247/661 (37%)

1.86 (1.41, 2.45)

 < 0.001

Creatinine > = 2 mg/dL

1230

130/174 (75%)

493/1056 (47%)

1.77 (1.18, 2.65)

0.005

HGB < 10 g/dL

1230

288/429 (67%)

335/801 (42%)

1.55 (1.16, 2.06)

0.003

Platelet Count < 150 × 10^9/L

1230

163/218 (75%)

460/1012 (45%)

2.26 (1.59, 3.22)

 < 0.001

  1. P-value from Wald chi-square test in logistic regression. NS2–Multivariate results not statistically significant at 0.05 level. Univariate p-values reported regardless of significance. Multivariate model uses stepwise selection with entry level 0.1 and variable remains if meets the 0.05 level. A multivariate p-value greater than 0.05 indicates variable forced into model with significant variables chosen using stepwise selection
  2. OR odds ratio, 95% CI 95% confidence interval
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