Table 1 Risk loci demonstrating association of alleles at respective loci in both chronic lymphocytic leukaemia (CLL) and multiple myeloma (MM)

From: Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology

Locus

Discovery GWAS

Sentinel variant

Correlated variant

Position (hg19)

Risk allele

Odds Ratio

P-value

CLL

MM

CLL

MM

CLL

MM

2q31.1

MM

rs4325816

 

174,808,899

T

T

1.11

1.12

2.0 × 10−3

6.4 × 10−7

   

rs72919402

174,750,200

T

-

1.13

-

4.6 × 10−4

-

3q26.2

MM & CLL

rs1317082

 

169,497,585

A

A

1.20

1.19

7.1 × 10−8

2.2 × 10−16

   

rs3821383

169,489,946

A

A

1.20

1.18

4.2 × 10−8

4.5 × 10−15

6p25.3

CLL

rs872071

 

411,064

G

G

1.37

1.10

2.8 × 10−27

7.5 × 10−7

   

rs1050976

408,079

T

T

1.37

1.10

1.9 × 10−27

3.7 × 10−7

6p22.3

MM

rs34229995

 

15,244,018

G

G

1.37

1.36

8.5 × 10−3

5.6 × 10−8

   

rs13197919

15,282,334

T

T

1.35

1.32

1.3 × 10−3

3.42 × 10−7

7q31.33

MM

rs58618031

 

124,583,896

T

T

1.15

1.11

3.2 × 10−5

1.7 × 10−7

   

rs59294613

124,554,267

C

-

1.16

-

4.4 × 10−6

-

8q24.21

MM

rs1948915

 

128,222,421

C

C

1.17

1.15

7.6 × 10−7

2.5 × 10−12

   

-

-

-

-

-

-

-

-

10q23.31

CLL

rs6586163

 

90,752,018

A

A

1.28

1.06

1.1 × 10−16

1.8 × 10−3

   

rs7082101

90,741,615

-

C

-

1.06

-

8.2 × 10−4

11q23.2

CLL

rs11601504

 

113,526,853

C

C

1.20

1.09

2.3 × 10−5

8.5 × 10−4

   

-

-

-

-

-

-

-

-

16q23.1

MM

rs7193541

 

74,664,743

T

T

1.12

1.12

1.0 × 10−4

3.7 × 10−10

 

CLL

 

-

-

-

-

-

-

-

-

22q13.33

 

rs140522

 

50,971,266

T

T

1.17

1.08

3.7 × 10−7

1.2 × 10−4

   

-

-

-

-

-

-

-

-

  1. - indicates SNP not present in filtered data