Table 1 Risk loci demonstrating association of alleles at respective loci in both chronic lymphocytic leukaemia (CLL) and multiple myeloma (MM)
Locus | Discovery GWAS | Sentinel variant | Correlated variant | Position (hg19) | Risk allele | Odds Ratio | P-value | |||
---|---|---|---|---|---|---|---|---|---|---|
CLL | MM | CLL | MM | CLL | MM | |||||
2q31.1 | MM | rs4325816 | 174,808,899 | T | T | 1.11 | 1.12 | 2.0 × 10−3 | 6.4 × 10−7 | |
rs72919402 | 174,750,200 | T | - | 1.13 | - | 4.6 × 10−4 | - | |||
3q26.2 | MM & CLL | rs1317082 | 169,497,585 | A | A | 1.20 | 1.19 | 7.1 × 10−8 | 2.2 × 10−16 | |
rs3821383 | 169,489,946 | A | A | 1.20 | 1.18 | 4.2 × 10−8 | 4.5 × 10−15 | |||
6p25.3 | CLL | rs872071 | 411,064 | G | G | 1.37 | 1.10 | 2.8 × 10−27 | 7.5 × 10−7 | |
rs1050976 | 408,079 | T | T | 1.37 | 1.10 | 1.9 × 10−27 | 3.7 × 10−7 | |||
6p22.3 | MM | rs34229995 | 15,244,018 | G | G | 1.37 | 1.36 | 8.5 × 10−3 | 5.6 × 10−8 | |
rs13197919 | 15,282,334 | T | T | 1.35 | 1.32 | 1.3 × 10−3 | 3.42 × 10−7 | |||
7q31.33 | MM | rs58618031 | 124,583,896 | T | T | 1.15 | 1.11 | 3.2 × 10−5 | 1.7 × 10−7 | |
rs59294613 | 124,554,267 | C | - | 1.16 | - | 4.4 × 10−6 | - | |||
8q24.21 | MM | rs1948915 | 128,222,421 | C | C | 1.17 | 1.15 | 7.6 × 10−7 | 2.5 × 10−12 | |
- | - | - | - | - | - | - | - | |||
10q23.31 | CLL | rs6586163 | 90,752,018 | A | A | 1.28 | 1.06 | 1.1 × 10−16 | 1.8 × 10−3 | |
rs7082101 | 90,741,615 | - | C | - | 1.06 | - | 8.2 × 10−4 | |||
11q23.2 | CLL | rs11601504 | 113,526,853 | C | C | 1.20 | 1.09 | 2.3 × 10−5 | 8.5 × 10−4 | |
- | - | - | - | - | - | - | - | |||
16q23.1 | MM | rs7193541 | 74,664,743 | T | T | 1.12 | 1.12 | 1.0 × 10−4 | 3.7 × 10−10 | |
CLL | - | - | - | - | - | - | - | - | ||
22q13.33 | rs140522 | 50,971,266 | T | T | 1.17 | 1.08 | 3.7 × 10−7 | 1.2 × 10−4 | ||
- | - | - | - | - | - | - | - |