Table 1 Distribution of the main characteristic between the long-term survival group and the remainder population (univariate analysis)
Variable | Long-term survival, n (%) | Remainder, n (%) | p-Value |
|---|---|---|---|
Age | n = 81 | n = 354 | p = n.s. |
<75 years | 56 (69.1) | 224 (63.2) | |
Gender | n = 81 | n = 354 | p = n.s. |
Male | 46 (56.8) | 178 (50.3) | |
Protocol | n = 81 | n = 354 | p = n.s. |
GEM05MAS65 | 44 (54.3) | 206 (58.2) | |
GEM2010MAS65 | 37 (45.7) | 148 (41.8) | |
Durie stage | n = 81 | n = 352 | p = n.s. |
I | 12 (14.8) | 29 (8.2) | |
II | 42 (51.8) | 168 (47.8) | |
III | 27 (33.3) | 155 (44) | |
ISS | n = 80 | n = 350 | p = 0.036 |
ISS 1 | 28 (35) | 78 (22.3) | |
ISS 2 | 33 (41.2) | 151 (43.1) | |
ISS 3 | 19 (23.8) | 121 (34.6) | |
R-ISS | n = 80 | n = 350 | p = 0.002 |
R-ISS 1 | 24 (30) | 58 (16.6) | |
R-ISS 2 | 55 (68.8) | 256 (73.1) | |
R-ISS 3 | 1 (1.2) | 36 (10.3) | |
Hemoglobin (g/dl) | n = 81 | n = 354 | p = 0.001 |
Hb ≥ 12 g/dl | 28 (34.6) | 63 (17.8) | |
Creatinine (mg/dl) | n = 81 | n = 354 | p = n.s. |
Creat < 1.1 | 54 (66.7) | 242 (68.4) | |
LDH | n = 81 | n = 348 | p = 0.009 |
Normal | 79 (97.5) | 305 (87.6) | |
Cytogenetics | n = 75 | n = 335 | p = 0.04 |
Standard risk | 68 (91) | 271 (80.9) | |
Response | n = 81 | n = 327 | p = 0.001 |
CR (sCR + CR IF-) | 47 (58) | 109 (33.3) | |
VGPR | 27 (33.3) | 161 (49.2) | |
PR | 4 (4.9) | 45 (13.8) | |
SD | 3 (3.7) | 11 (3.4) | |
PD | 0 (0) | 1 (0.3) | |
BM signature | n = 77 | N = 323 | p < 0.001 |
MGUS-like profile | 12 (15.6) | 12 (3.7) | |
MM-like profile | 68 (84.4) | 311 (96.3) | |
MRD | n = 81 | n = 354 | p < 0.001 |
Negative | 35 (41.9) | 35 (9.9) |
