Table 2 Pathologic summary

Case	Tissue 1	Anatomic distribution	Amyloid biopsy 1	Tissue 2	Interval (months)	Anatomic distribution	Amyloid biopsy 2	Focus of therapy
1	Stomach	Interstitial = ATTR; Vascular = ATTR	ATTR	Fat	4	NA	SAA	Nil
2	Heart	Interstitial = ATTR	ATTR	Fat	0	NA	AIns	ATTR
3	Kidney	Vascular = AL	AL (λ)	BM	2	Periosteal fibrous tissue = ATTR	ATTR	AL
4	Heart	Vascular = ATTR	ATTR	Duodenum	0	Interstitial = A-IA	A-IA	Nil**
5	BM	Periosteal fibrous Tissue = AL & ATTR	Hybrid AL (λ) and ATTR	Fat	0	NA	AL (λ)	AL
6^	BM	Periosteal fibrous tissue = AL & ATTR	Hybrid AL (κ) and ATTR	Lymph node	0	Globular = AL predominant	AL (κ) predominant	AL
7	Heart	Vascular = AL; Interstitial = ATTR Predominant	AL (λ) and ATTR*	Kidney	4	Vascular = AL	AL (λ)	Nil***
8	BM	Periosteal fibrous tissue = AL	AL (κ)	BM	130	Periosteal fibrous tissue = AL and ATTR	Hybrid AL (κ) and ATTRm	AL
9^^	Fat	NA	AL (λ)	Heart	1	Vascular = AL and ATTR; interstitial = AL and ATTR	Hybrid AL(λ) and ATTR	AL and ATTR

^*Amyloid subtype varied depending on anatomic distribution. See Fig. 1
^**Amyloidoses were diagnosed postmortem
^***Patient expired prior to institution of therapy
^{^}Heart biopsy 6 years later demonstrated vascular involvement by AL (κ) predominant amyloid
^{^^}Prostate biopsy from 4 years earlier was retrospectively analyzed for amyloid, demonstrating AL (λ) amyloid in a vascular distribution
ATTR transthyretin amyloidosis, ATTRm hereditary transthyretin amyloidosis, AL immunoglobulin light chain amyloidosis, A-IA immunoglobulin-associated amyloidosis, SAA serum amyloid A amyloidosis, AIns insulin-derived amyloidosis, BM bone marrow

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