Table 2 Summary of treatment-emergent adverse events
Maximum grade, n (%) | ||||
|---|---|---|---|---|
Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
Thrombocytopeniaa | 4 (11) | 6 (17) | 9 (26) | 3 (9) |
Blurred vision | 2 (6) | 15 (43) | 1 (3) | 0 |
Cough | 11 (31) | 3 (9) | 0 | 0 |
Increased aspartate aminotransferase | 8 (23) | 3 (9) | 2 (6) | 0 |
Dry eye | 6 (17) | 6 (17) | 1 (3) | 0 |
Nausea | 9 (26) | 2 (6) | 0 | 0 |
Anaemia | 0 | 4 (11) | 6 (17) | 0 |
Diarrhoea | 6 (17) | 2 (6) | 2 (6) | 2 (6) |
Photophobia | 7 (20) | 3 (9) | 0 | 0 |
Pyrexia | 6 (17) | 4 (11) | 0 | 0 |
Chills | 7 (20) | 2 (6) | 0 | 0 |
Fatigue | 2 (6) | 6 (17) | 0 | 0 |
Upper respiratory tract infection | 5 (14) | 3 (9) | 0 | 0 |
Increased alanine aminotransferase | 5 (14) | 2 (6) | 0 | 0 |
Back pain | 3 (9) | 2 (6) | 2 (6) | 0 |
Constipation | 5 (14) | 1 (3) | 1 (3) | 0 |
Increased γ-glutamyl transferase | 2 (6) | 3 (9) | 2 (6) | 0 |
Arthralgia | 2 (6) | 3 (9) | 1 (3) | 0 |
Increased blood alkaline phosphatase | 6 (17) | 0 | 0 | 0 |
Dyspnoea | 4 (11) | 1 (3) | 1 (3) | 0 |
Contusion | 5 (14) | 0 | 0 | 0 |
Decreased appetite | 3 (9) | 2 (6) | 0 | 0 |
Headache | 4 (11) | 1 (3) | 0 | 0 |
Sinusitis | 0 | 5 (14) | 0 | 0 |
Eye pain | 3 (9) | 0 | 1 (3) | 0 |
Hypokalaemia | 1 (3) | 0 | 3 (9) | 0 |
Infusion-related reaction | 1 (3) | 2 (6) | 1 (3) | 0 |
Lung infection | 0 | 1 (3) | 3 (9) | 0 |
Pneumonia | 0 | 1 (3) | 3 (9) | 0 |
Urinary tract infection | 0 | 3 (9) | 1 (3) | 0 |
Hypertension | 1 (3) | 1 (3) | 1 (3) | 0 |
Keratitis | 0 | 1 (3) | 2 (6) | 0 |
Decreased neutrophil count | 0 | 0 | 3 (9) | 0 |
Haematuria | 0 | 1 (3) | 1 (3) | 0 |
Neutropenia | 0 | 0 | 1 (3) | 1 (3) |
Rib fracture | 1 (3) | 0 | 1 (3) | 0 |
Toothache | 0 | 1 (3) | 1 (3) | 0 |
Appendicitis | 0 | 0 | 1 (3) | 0 |
Bacteraemia | 0 | 0 | 0 | 1 (3) |
Increased blood lactate dehydrogenase | 0 | 0 | 1 (3) | 0 |
Cataract | 0 | 0 | 1 (3) | 0 |
Cholecystitis acute | 0 | 0 | 0 | 1 (3) |
Cholecystitis infective | 0 | 0 | 0 | 1 (3) |
Deep vein thrombosis | 0 | 0 | 1 (3) | 0 |
Encephalopathy | 0 | 0 | 1 (3) | 0 |
Fall | 0 | 0 | 1 (3) | 0 |
Febrile neutropenia | 0 | 0 | 1 (3) | 0 |
Gastroenteritis | 0 | 0 | 1 (3) | 0 |
Humerus fracture | 0 | 0 | 1 (3) | 0 |
Lower respiratory tract infection | 0 | 0 | 1 (3) | 0 |
Pericardial effusion | 0 | 0 | 0 | 1 (3) |
Pneumonia haemophilus | 0 | 0 | 1 (3) | 0 |
Respiratory tract infection | 0 | 0 | 1 (3) | 0 |
Retinal detachment | 0 | 0 | 1 (3) | 0 |
Salmonellosis | 0 | 0 | 1 (3) | 0 |
Syncope | 0 | 0 | 1 (3) | 0 |
Abnormal visual acuity tests | 0 | 0 | 1 (3) | 0 |
