Table 3 Factors affecting prognosis in MDS patients without hematopoietic stem cell transplantation or induction chemotherapy (n = 721) in univariate analysis and two multivariate models (multivariate I: absolute lymphocyte count < 1.2 × 109/l together with the cytogenetic risk groups according to IPSS-R; multivariate II: absolute lymphocyte count < 1.2 × 109/l together with the cytogenetic risk groups according to IPSS-R, bone marrow blast count and the degree of cytopenias)

From: Lymphopenia at diagnosis is highly prevalent in myelodysplastic syndromes and has an independent negative prognostic value in IPSS-R-low-risk patients

 

Univariate

Multivariate I

Multivariate II

 

p

Hazard ratio

95% confidence interval

p

Hazard ratio

95% confidence interval

p

Hazard ratio

95% confidence interval

Age ≥ 65

<0.001

2.32

1.87

2.86

        

Male gender

0.005

1.15

1.04

1.26

        

Hb < 10 g/dl

<0.001

1.47

1.21

1.78

    

<0.001

1.56

1.29

1.89

Neutrophil count < 1.8 × 109/l

0.001

1.39

1.15

1.67

    

0.959

1.0

0.82

1.23

Platelet count < 100 × 109/l

<0.001

1.88

1.56

2.27

    

<0.001

1.56

1.28

1.89

Bone marrow blasts > 5%

<0.001

2.60

2.13

3.18

    

<0.001

2.25

1.82

2.79

IPSS-R cytogenetic risk category

<0.001

1.55

1.41

1.69

<0.001

1.52

1.39

1.67

<0.001

1.38

1.26

1.51

IPSS-R category

<0.001

1.68

1.55

1.82

        

Transfusion dependency

0.001

1.73

1.27

2.36

        

LDH > ULN (240 U/l)

<0.001

1.91

1.53

2.38

        

Absolute lymphocyte count < 1.2 × 109/l

0.001

1.35

1.13

1.63

0.022

1.24

1.03

1.49

0.086

0.85

0.70

1.02

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