Table 5 Additional prognostic value of different factors for patients within the IPSS-R low-risk group without hematopoietic stem cell transplantation or induction chemotherapy (n = 265)

From: Lymphopenia at diagnosis is highly prevalent in myelodysplastic syndromes and has an independent negative prognostic value in IPSS-R-low-risk patients

 

Unvariate

Multivariate

 

p Value

Hazard ratio

95% CI

p Value

Hazard ratio

95% CI

Age > 65

<0.001

3.31

2.25

4.88

<0.001

3.21

2.15

4.80

LDH > ULN (240 U/l)

<0.001

2.31

1.51

3.53

<0.001

2.58

1.67

3.98

Absolute lymphocyte count <1.2 × 109/l

0.002

1.68

1.21

2.34

0.033

1.46

1.03

2.08

Male gender

0.054

1.39

0.99

1.93

    

Transfusion dependency

0.075

1.61

0.95

2.71

    

Bone marrow fibrosis

0.691

0.87

0.45

1.69

    

Hb < 10 g/dl

0.287

1.20

0.86

1.66

    

Neutrophil count < 1.8 × 109/l

0.148

0.79

0.57

1.09

    

Platelet count < 100 × 109/l

0.174

0.73

0.47

1.15

    

Bone marrow blasts > 5%

0.916

1.04

0.49

2.23

    

IPSS-R cytogenetic risk category

0.213

1.44

0.81

2.57

    
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