Table 1 Molecular features of iPET-negative and iPET-positive DLBCL

From: Molecular characteristics of diffuse large B-cell lymphoma in the Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin lymphomas (PETAL) trial: correlation with interim PET and outcome

 

Cell of origin

 

GCB n = 102

ABC n = 122

Unclass. n = 7

 

n

%

n

%

n

%

iPET-negative

90/206

43.7

110/206

53.4

6/206

2.9

iPET-positive

12/25

48

12/25

48

1/25

4

 

p = 0.6772a

 

Translocations

 

MYC

BCL2

BCL6

DH

 

Amp n = 48

%

Break n = 27

%

Break n = 22

%

Break n = 37

%

n = 16

%

iPET-negative

44/229

19.2

21/229

9.2

18/89

20.2

32/93

34.4

13/227

5.7

iPET-positive

4/24

16.7

6/24

25

4/13

30.8

5/11

45.5

3/22

13.6

 

p = 1.0000

p = 0.0291

p = 0.4701

p = 0.5153

p = 0.1571

  1. GE gene expression, GCB germinal center like, ABC activated B-cell like, unclass. unclassified, FISH fluorescence in situ hybridization, Amp amplification, DH double-hit, n indicates number of positive/number of all cases with data
  2. aFisher's exact test GCB versus non-GCB
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